Research progress on role of pyroptosis in pathogenesis of myelodyplastic syndrome

Pyroptosis is the programmed cell death mediated by inflammatory cysteine-aspartic protease (Caspase). Intercallular or extracellular pathogens can promote the formation of inflammatory by activating Caspase-1, Caspase-4/5/11, pro-interleukin (IL)-1β and pro-IL-18. The activated inflammatory cytokines lead to cell lysis and inflammatory factors release, and finally induced cell death.The alterations of Toll like receptor(TLR) signaling pathway and bone microenvironment, and presence of inflammasome could cause the formation of an inflammatory environment, leading to myelodyplastic syndrome (MDS). The article reviews the mechanism of pyroptosis and the relationship between pyroptosis and MDS. Key words: Pyroptosis; Myelodyplastic syndrome; Caspases; Interleukin-1beta; Interleukin-18