Design, synthesis and evaluation of potential inhibitors for poly(ADP-ribose) polymerase members 1 and 14.

Caleb M. Kam,Amanda L. Tauber,Stephan M. Levonis,Stephanie S. Schweiker

Design, synthesis and evaluation of potential inhibitors for poly(ADP-ribose) polymerase members 1 and 14.

2020

Caleb M. Kam
Amanda L. Tauber
Stephan M. Levonis
Stephanie S. Schweiker

Poly(ADP-ribose) polymerase (PARP) members PARP1 and PARP14 belong to an 18-member superfamily of post-translational modifying enzymes. A library of 9 novel non-NAD analog amine compounds was desig...

Keywords:

Reductive amination
Amine gas treating
PARP1
Docking (molecular)
Poly ADP ribose polymerase
Enzyme
Chemistry
Biochemistry
Polymerase
design synthesis

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