Interpretation of the multinucleated giant cell in human trophoblast cultures.

Morphology of human trophoblast culture has been studied in relation to certain conditions such as duration of the pregnancy, age of the culture, and strength of the trypsinization. ‘Multinucleated giant cells’ appear to be actually fortuitous transversal sections of chorionic buds. Their presence and aspects depend on the degree of trypsinization. Origin of epithelioid polygonal cells and of fibroblast cells is discussed.