Structural and functional studies of the Ras-associating and pleckstrin-homology domains of Grb10 and Grb14

Grb10 and Grb14 are adaptor proteins that inhibit insulin signaling through direct interactions with the insulin receptor kinase domain. Structural and functional studies now reveal that the tandem Ras-associating and pleckstrin-homology domains of these proteins are necessary for membrane recruitment and insulin receptor inhibition.