One kind of crystal form I bisoprolol fumarate and its preparation method

The present application relates to the field of pharmaceutical polymorphs, particularly Form I and bisoprolol relates to a process for preparing fumarate; mild prepared using the method of the present application bisoprolol fumarate crystal form, the reaction conditions, simple, reproducible and good single recrystallization, bisoprolol fumarate can significantly improve the yield and quality and high purity, good dissolution effect, polymorph stable quality, industrial production conditions such that a controlled, more suitable for mass production.