Effects of propofol on respiratory mechanic and lung histology in normal rats

Background Propofol is able to reduce airway resistance in lungs with previous airway constriction. The aim of this study was to evaluate the effects of propofol on respiratory mechanics in normal rats and to correlate these parameters with lung histology, to define the sites of action of propofol. Methods Sixteen Wistar rats were divided into two groups of eight animals. Rats were sedated (diazepam) and anaesthetized with pentobarbital sodium (C) or propofol (P), and paralysed. Respiratory system, lung, and chest wall resistive, elastic, and viscoelastic/inhomogeneous pressures were computed using the end-inflation occlusion method. Results Lung resistive pressure was smaller in group P (0.29 kPa (0.05)) than group C (0.37 kPa (0.04)) ( P =0.007). The internal diameter of the central airways was greater in group P than C ( P =0.01). Conclusion Propofol acts at the airway level decreasing respiratory system and lung impedances as a result of central airway dilation.