A low-noise miniaturized patch-clamp amplifier

We present measurement results from a low-noise miniaturized patch-clamp amplifier with electrode compensation. The patch clamp amplifier has less than 4 pA of rms noise at a 10 kHz bandwidth and is capable of accurately measuring nano-Amperes of current. The device measurements shown here show that the integrated amplifier can be used for the design of high-density patch-clamp arrays.