ANTIDIABETIC ACTIVITY OF CLERODENDRUM PHILIPPINUM SCHAUER LEAVES IN STREPTOZOTOCIN INDUCED DIABETIC RATS

Objective: The present study has been undertaken to evaluate the antidiabetic activity of Clerodendrum philippinum Schauer leaves. Methods: The fresh leaves were collected from Kuruan village of Jajpur district in the state of Odisha, India and extracted successively with n -hexane, methanol and water. The effect of extracts at the dose level of 400 mg/kg body weight was studied in normal, glucose loaded and streptozotocin-induced diabetic rats. Results: The test extracts showed significant reduction of blood glucose level in normal, glucose loaded and streptozotocin-induced diabetic rats. Methanol extract demonstrated maximum blood glucose lowering potential as compared to other extracts. Conclusion: The leaf of Clerodendrum philippinum Schauer is endowed with blood sugar lowering potential in both normal and diabetic rats.