Assessment of Galectin-1, Galectin-3, and PGE2 Levels in Patients with COVID-19.

It is important to determine the inflammatory biomarkers in the severity of Coronavirus Disease 2019 (COVID-19) with the emergence of the pandemic. Galectins and prostaglandins play important roles in the regulation of immune and inflammatory responses. Therefore, this study aimed to investigate Galectin-1 (Gal-1), Galectin-3 (Gal-3), and prostaglandin E2 (PGE2) levels in patients with COVID-19. Gal-1, Gal-3, and PGE2 serum concentrations were measured using enzyme-linked immunosorbent analysis (ELISA) on 84 COVID-19 patients (severe=29 and nonsevere=55) and 56 healthy controls. In this study, the increased levels of Gal-1 (median, 9.86, 6.35, 3.67 ng/ml), Gal-3 (median, 415.31, 326.33, 243.13 pg/ml)and PGE2 (median, 193.17, 192.58, 124.62 pg/ml) levels were found in patients with COVID-19 than healthy controls (p<0.001 for all). In the severe group, Gal-3 levels were higher while there were no differences in Gal-1 and PGE2 levels (p=0.011, p=0.263, p=0.921, respectively). There was a positive correlation between serum Gal-1 and Gal-3 levels (ρ=0.871, p<0.001). Gal-3, C-reactive protein, lymphocyte count, and age were found as independent predictors of the disease severity (p=0.002, p=0.001, p=0.007, and p=0.003, respectively). With the emergence of effective drug needs in the COVID-19 pandemic, differentiation of severe disease is important. Gal-3 could be a potential prognostic biomarker of COVID-19.