Long term results of pati ents with hairy cell leukemia treated with cladribine

6701 Background: Hairy cell leukemia is a chronic B-cell lymphoproliferative disorder involving bone marrow and spleen. A high complete response rate utilizing cladribine with long durable responses and survival has been documented in a large series (G. Goodman, et al, J. Clin. Onc. 21:891–896, 2003). We have reviewed our long-term experience with hairy cell leukemia treated with cladribine. Methods: We reviewed the results of all patients who had received cladribine ≥5 years ago. From 1992–2000 13 patients received cladribine 0.1 mg/kg/d continuous I.V. infusion for 7 days. Each received one course and were re-evaluated. Patients in complete remission were followed without additional treatment. Patient Characteristics: There were 11 males and 2 females. The ages ranged from 37–76 years (median 54 years). Ten patients were previously untreated. Four patients had previously received interferon with two also receiving prior pentostatin. Responses and Survival: Complete responses characterized by normal bloo...