Estimation of Biochemical Changes in Diabetic Patients

Diabetes mellitus is a heterogeneous metabolic disorder characterized by hyperglycaemia resulting from defective insulin secretion, resistance to insulin action or both.. The role of trace elements in some of the metabolic dysfunctions and their contributions in the development of vascular complications is not clear. Therefore, the present study investigates the relationship among diabetes mellitus, trace elements status, lipid profiles in the serum of 50 diabetes mellitus patients and healthy subjects. The serum level of Cu was increased, whereas, Zn, Mg and Ca levels were significantly decreased in diabetic patients as compared to the healthy subjects. The levels of total cholesterol (CHOL), triglyceride (TG) and low-density lipoprotein-cholesterol (LDL) were higher in diabetes mellitus in comparison to the healthy subjects. The mean value of highdensity lipoprotein cholesterol (HDL) was lower in diabetic patients. These findings may explain the role of impaired trace element status.