The I[kappa]B kinase complex regulates the stability of cytokine-encoding mRNA induced by TLR-IL-1R by controlling degradation of regnase-1
2011
The stability of interleukin 6 transcripts is negatively regulated by the RNAse regnase-1. Akira and colleagues show that regnase-1 is targeted for degradation by phosphorylation mediated by the kinase IKK, which allows more interleukin 6 production.
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