Halogenated quinoline compound and preparation method thereof

2016 
The application belongs to the technical field of synthetic chemistry, and particularly relates to a halogenated quinoline compound and a preparation method thereof. The invention provides a novel halogenated quinoline compound and a preparation method thereof. According to the preparation method, a 2-vinylquinoline compound is mixed and reacts with concentrated hydrochloric acid to prepare a 2-chloroethyl quinoline compound, the reaction condition is mild, other catalysts are not needed, the operation steps are simple, and the preparation method is safe and reliable. The preparation method is suitable for multiple quinoline reaction substrates, the synthetic yield reaches 80-95%, and by virtue of optimization and adjustment of the reaction substrates, and polysubstituted and structurally diverse halogenated quinoline compounds can be synthesized, so that the preparation method is suitable for industrial production.
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