FORMULATION AND EVALUATION OF FAST DISSOLVING TABLETS OF SUMATRIPTAN SUCCINATE

In this study, Fast dissolving tablets of Sumatriptan Succinate has been prepared by dry granulation to improve dissolution rate of drug in oral cavity for better patient’s compliance & effective therapy. Sumatriptan Succinate is widely used in the treatment of migraine and cluster headache. Migraine caused by temporary swelling of blood vessels in head. The main objective of this study was to formulate fast dissolving tablets of Sumatriptan succinate to achieve a better dissolution rate and further improvement in the bioavailability of the drug. It has low oral bioavailability due to first pass metabolism and incomplete absorption. Fast dissolving tablets of Sumatriptan succinate were prepared with combination of superdisintegrants like Kollidon CL (crospovidone), AC-DI-SOL (croscarmellose sodium), and Starch-1500 (Pregelatinised starch) by using the dry granulation and compression method. The all (formulations) compressed tablets were evaluated for thickness, uniformity of weight, drug content, hardness, friability, wetting time, in vitro and in vivo disintegration time, in vitro drug release and microbial evaluation. It has been evaluated that formulation batch F3 contains superdisintegrants i.e. Kollidon-CL (4%), Ac-di-sol (1.5%), which exhibit the promising results in term of enhanced dissolution rate, wetting time and disintegration time and leads to improved bioavailability, effectiveness and better patient’s compliance. In this study, Fast dissolving tablets (F1-F8) has also been subjected to microbial contamination study, as that presence of microbial flora may affect the quality, safety and efficacy of the product’s activity. It has been evaluated that the presences of total aerobic bacterial counts were found less than 100cfu while fungal colonies were found nil.ration time, in vitro drug release.