Autologous Peripheral Blood Purified Stem Cells Transplantation for Treatment of Systemic Lupus Erythematosus

"Lupus", from the Latin in the 19th century, had appeared in the West before and after the medical literature. In 1828, the French dermatologist Bette (Biett) firstly reported such a patient: facial skin has erythema the same as the the wolf bites. To the mid-19th century, there was a doctor named Carson Musharraf formally using the "lupus" (lupus erythematosus, LE) as the medical terminology, which only refered to skin lesions of discoid lupus erythematosus then. With the development of medical science and clinical practice, more and more doctors found that lupus is not only skin damage, but also associated with kidney, brain, heart, lungs, nerves, muscles and joints, blood and other systemic diseases. To the 1890s, American doctor Osler (Osler) proposed the disease as "systemic lupus erythematosus" (systemic lupus erythematosus, SLE) [1]. Systemic lupus erythematosus (SLE), a common autoimmune disease without explicit etiology, has a high incidence of secondary infection, treatment difficulties and high mortality, arousing the focus of domestic and foreign scholars. According to the prevalence rate from 70 to 100/10 million people [2], China has reached to 1.12 million patients which is constituted mainly by young women. In addition to involving the outer skin, the disease violates various body organs, including vital organs such as the nervous system, heart, kidney and so on, the central nervous system such as meningitis, encephalitis, acute cerebrovascular disease, spinal cord inflammation and subarachnoid hemorrhage, even to death. It is the most common when occurring cardiac involvement, such as pericarditis, pericardial effusion heart attack, and life-threatening acute cardiac tamponade, which affect the quality of life. Involving the kidneys, it may be kidney failure. Respiratory system involvement includes bronchial pneumonia, pleurisy, atelectasis and respiratory failure. Secondary infection is a common complication of SLE, causing death at worst. SLE is considered a typical multi-organ involvement autoimmune disease, as a result of the disorder of immune system[3,4]. Before the 1960s, the 5-year survival rate was below 50%. With the progress of the treatment and the development of therapeutic drugs, especially corticosteroids and cytotoxic drugs for SLE, the survival rate has improved significantly, has