Statistical Analysis of Renal Clearance by the Dog.

SummaryFrom data accumulated over a 6-year period on 31 trained, unanesthetized female dogs the following mean values for several renal functions were calculated: glomerular filtration rate (creatinine clearance) = 94 ml/min./sq. M surface area; renal plasma flow (p-aminohippurate clearance following its oral administration) =238 ml/min./sq. M; p-aminohippurate Tm = 16.5 mg/min./sq. M; arginine Tm = 12.9 mg/ min./sq. M; simultaneous (creatinine) GF/ p-aminohippurate RPF filtration fraction = 0.40; and GF/penicillin RPF “filtration fraction” = 0.35. A statistical analysis of the variability of the results was presented and the significance of the data was discussed.