Additional file 1: Figure S1. of Methylome analysis for spina bifida shows SOX18 hypomethylation as a risk factor with evidence for a complex (epi)genetic interplay to affect neural tube development

Whole genome methylation in MMC patients versus controls. Unsupervised hierarchical clustering analysis of the subgroups. Methylation values for LINE-1 and LINE-2 repetitive elements are extracted from data obtained with the HM450k. Heatmaps represent 3575 randomly selected CpGs (1 % total CpGs). Green and red represent 0 and 1 methylation, respectively. MMC: myelomeningocele. (TIF 10684 kb)