The influence of various maintenance immunosuppressive drugs on lymphocele formation and treatment after kidney transplantation

ABSTRACTPurpose: We compared the incidence of lymphocele formation and treatment in kidney transplant recipients given 3 immunosuppressive drug regimens.Materials and Methods: Consecutive series of adult kidney only recipients, including group 1—152 who received sirolimus/mycophenolate mofetil (MMF)/prednisone (P), group 2—168 who received cyclosporine/MMF/P and group 3—193 who received cyclosporine/azathioprine/P, were analyzed for post-transplantation lymphocele formation. All available records and imaging studies were reviewed, such as ultrasound, computerized tomography, magnetic resonance imaging etc, for peritransplant fluid collections greater than 2.5 cm. Demographic characteristics and the risk factors for lymphocele were compared in these 513 recipients using univariate and multivariate analysis.Results: The overall incidence of lymphocele formation was 174 of 513 cases (33.9%) and the incidence of treated lymphoceles was 81 of 513 (15.7%). In groups 1 to 3 the incidence was 45.5%, 33.9% and 24....