Procedures for Improving Therapeutic Gain

A number of studies (Bhuyan et al., 1977; Freeman et al., 1980; Kim et al., 1980; Haveman, Hahn, 1981) have determined that the best conditions to realize a maximum antitumor hyperthermia (HT) effect are the following: low pH, hypoxia, slow blood flow, deficiency of nutrients and energy and increase in cell numbers in the S-phase of a cell cycle. It was shown that tumor tissue pH is selectively decreased under induced hyperglycemia (IHG) (see the reviews by Wike-Hooley et al., 1984; Zavrid et al., 1987).According to this phenomenon von Ardenne (1966, 1972) has suggested the use of IHG for enhancement of thermosensitivity.