No relationship between SRY variants and risk of Parkinson’s disease in Chinese population

Abstract Parkinson’s disease (PD) is a common neurodegenerative disease with inherent sex differences and SRY is a gene located in Y chromosome which encodes a transcription factor involving the regulation of dopamine system. In this study, we investigated whether SRY variants were associated with PD in Chinese population. A total of 2058 male PD patients and 1650 male control subjects were recruited and variants in SRY transcript and flanking regions were genotyped by whole-exome sequencing or whole-genome sequencing. Analysis of rare variants by optimal sequence kernel association test showed no difference in variants burden of coding, 5’-noncoding and 3’-noncoding between case and control group. And of the 6 common variants identified, none showed a significant effect in altering PD risk in our population using logistic regression. Our results suggested SRY variants were not associated with the risk of PD in Chinese population.