N,O‐Bis(trimethylsilyl)acetamide

[10416-59-8] C8H21NOSi2 (MW 203.43) InChI = 1S/C8H21NOSi2/c1-8(9-11(2,3)4)10-12(5,6)7/h1-7H3/b9-8+ InChIKey = SIOVKLKJSOKLIF-CMDGGOBGSA-N (powerful silylating agent; reacts with a wide range of functional groups) Alternate Name: BSA. Physical Data: bp 71–73 °C/35 mmHg.1,2 Solubility: very sol most organic solvents. Form Supplied in: liquid; rapidly contaminated with trimethylsilylacetamide and acetamide if exposed to moist air. Drying: extreme moisture sensitivity; should be kept in a sealed container. Preparative Method: made by the reaction of acetamide with a large excess of Chlorotrimethylsilane in the presence of Triethylamine.1, 2 Handling, Storage, and Precautions: no special handling and storage procedures; all work must be carried in an efficient fume hood.