SYNTHESIS OF (S)-MAPPICINE AND MAPPICINE KETONE VIA RADICAL CASCADE REACTION OF ISONITRILES

Abstract ( S )-Mappicine ( 2 ) and mappicine ketone ( 1 ) have been prepared from methylacetoacetate ( 4 ) by a strategy featuring a radical cascade reaction of an isonitrile as the key step. The introduction of the hydroxy group of ( S )-mappicine occurred with moderate selectivity through asymmetric hydroxylation.