Preparation method for pharmaceutical crystal form of febuxostat
2016
The invention discloses a preparation method for a pharmaceutical crystal form of febuxostat. The preparation method comprises the following steps: dissolving the febuxostat in an ethanol aqueous solution, and carrying out heating and dissolving under stirring; carrying out hot filtration, slowly cooling a filtrate, adding a seed crystal, carrying out stirring until a solid is separated, continuing cooling, maintaining the temperature, and carrying out crystallization; and carrying out filtering, placing a filter cake in a hot-air drying oven, and carrying out drying so as to obtain a product. The method provided by the invention has the advantages of simple and convenient operation, good repeatability, high product purity and yield, good crystal stability, and applicability to industrial production.
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