Calcitonin inhibits the increase in bone acid phosphatase activity by high dose of zinc in rats

Abstract The activity of femoral-epiphyseal acid phosphatase, a marker enzyme of bone resorption induced by parathyroid hormone, was increased by a single oral dose of Zn 100 mg/kg to rats. This increase was completely inhibited by calcitonin which has antagonistic effect on the action of parathyroid hormone on bone, thus supporting the hypothesis that the effect of Zn administration on bone may be mediated by parathyroid hormone.