A Sustainable Strategy for the Straightforward Preparation of 2H-azirines and Highly Functionalized NH-aziridines from Vinyl Azides Using a Single Solvent Flow-Batch Approach

The reported flow-batch approach enables the easy preparation of 2H-azirines and their stereoselective transformation into highly functionalized NH-aziridines, starting from vinyl azides and organolithiums. The protocol has been developed using cyclopentylmethylether (CPME) as an environmentally responsible solvent, resulting into a sustainable, safe and potentially automatable method for the synthesis of interesting strained compounds.