Comprehensive Breast Cancer Risk Assessment for CHEK2 and ATM Pathogenic Variant Carriers Incorporating a Polygenic Risk Score and the Tyrer-Cuzick Model.

Shannon Gallagher,Elisha Hughes,Allison W. Kurian,Susan M. Domchek,Judy Garber,Braden Probst,Brian J. Morris,Placede Tshiaba,Stephanie Meek,Eric Rosenthal,Benjamin B. Roa,Thomas P. Slavin,Susanne Wagner,Jeffrey N. Weitzel,Alexander Gutin,Jerry S. Lanchbury,Mark E. Robson

Comprehensive Breast Cancer Risk Assessment for CHEK2 and ATM Pathogenic Variant Carriers Incorporating a Polygenic Risk Score and the Tyrer-Cuzick Model.

2021

Shannon Gallagher
Elisha Hughes
Allison W. Kurian
Susan M. Domchek
Judy Garber
Braden Probst
Brian J. Morris
Placede Tshiaba
Stephanie Meek
Eric Rosenthal
Benjamin B. Roa
Thomas P. Slavin
Susanne Wagner
Jeffrey N. Weitzel
Alexander Gutin
Jerry S. Lanchbury
Mark E. Robson

PURPOSEBreast cancer risks for CHEK2 and ATM pathogenic variant (PV) carriers are modified by an 86-single nucleotide polymorphism polygenic risk score (PRS) and individual clinical factors. Here, ...

Keywords:

Tyrer-Cuzick Model
Internal medicine
Cancer
Single-nucleotide polymorphism
cancer risk assessment
Medicine
CHEK2
polygenic risk score
Oncology

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