The Intracellular Invasion Ability and the Associated Microbiological Characteristics of Streptococcus canis in Isolates from Japan.
2020
This study evaluated cell invasion ability (CIA) of Streptococcus canis isolates and clarified the relationship between high-frequency CIA and microbiological features. Of the companion animal-origin isolates (n = 117) in 2017, 40 isolates were randomly selected with the host information, and two human blood-origin isolates were included. We measured the CIA using human colon carcinoma epithelium and the hemolytic activity (HA) using sheep blood, along with S. canis M-like protein (SCM) allele typing, sequence type (ST) determination, and antimicrobial resistance (AMR) phenotyping/genotyping. CIA measurements revealed that 19 isolates were high-frequency and 24 isolates were low-frequency. The HA assessment revealed that 24 isolates were categorized as high-level and 19 isolates were low-level. There was no difference in the high/low-level HA between the high-frequency/low-frequency CIA populations. There was a significant difference in the high/low-frequency CIA between SCM group I/II populations. There was also significantly higher CIA in the SCM allele type 10/type 11 than in others. We found a significant association between high-frequency CIA and ST21/ST41 populations. There was no difference in the high/low-frequency CIA between the presence and absence of AMR phenotype/genotype. Our observations suggest a relationship between high-frequency CIA and its microbiological characteristics (SCM allele type 10/type 11 or ST21/ST41).
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