Research Journal of Pharmaceutical, Biological and Chemical Sciences Histo-pathological Analysis of Salivary Gland Lesions with Ki-67 Immunoprofile.

To evaluate the incidence, age and sex distribution of salivary gland lesions and to analyse the histopathological type and Ki-67 immunohistochemistry expressions in salivary gland tumors. Surgical specimens were fixed in 10% neutral buffered formalin. Sections of 5µ thickness were cut and stained with Hematoxylin and Eosin stains. Immunohistochemistry of Ki-67 was done in salivary gland tumors. The mean age for benign tumors, malignant tumors and non neoplastic lesions were 39, 49.05 and 33.33 yrs respectively with female predominance. The average Ki-67 labeling indexes for benign tumors were 1% and for malignant tumors were 17%. Pleomorphic adenoma was the most common benign tumor and adenoid cystic carcinoma was the most common malignant tumor. There was significantly higher frequency of Ki-67 positive cells in malignant salivary gland tumors compared to benign tumors.