Differential effects of IL-17 pathway in disseminated candidiasis and zymosan-induced multiple organ failure

The role of the IL-17 pathway in fungal sepsis remains controversial. Several studies suggested that IL-17 is crucial for the protection against Candida sepsis, while other studies reported that IL-17 may contribute to inflammatory pathology and worsening of fungal disease. To address these discrepancies, we assessed the differential role of IL-17 pathway in two models of fungal sepsis: intravenous infection with live Candida albicans, in which fungal growth is the main cause of mortality, and zymosan-induced multiple organ failure in which the inflammatory pathology drives the mortality.