Association of the chromosomal region 2q35 with type 1 diabetes mellitus in the Russian patients from Moscow

To map human chromosome 2 region associated with type 1 diabetes mellitus, 89 families with concordant and discordant sib pairs were analyzed. Linkage and association with type 1 diabetes were examined using polymorphic microsatellite markers spanning the region of about 4 Mb. The linkage plot was constructed, and association of the five microsatellite markers within the chromosomal region 2q35 was examined. Polymorphic marker D2S137 (Z′ = 3.225, pc = 0.0048) demonstrated maximum linkage and association with type 1 diabetes.