Effects of male chromosomal polymorphism on spermatozoa quality and the outcome of in vitro fertilization/intracytoplasmic sperm injection treatment

Objective To explore the effect of male chromosomal polymorphism on spermatozoa quality and in vitro fertilization/intracytoplasmic sperm injection-embryo transfer (IVF/ICSI-ET) outcomes. Methods A retrospective analysis was performed in 131 couples with male chromosomal polymorphism as study group, and 160 couples with normal chromosomes as control group. Results There was a statistically significant difference about the ratio of severe oligozoospermia/asthenospermia between study group (19.85%) and control group (5.00%, P<0.001). Yqh+ was the most frequently occurring in patients with severe oligozoospermia/asthenospermia (38.46%). The secondary was Yqh-(15.38%). 1qh+ was the most frequently occurring in men with autosomal polymorphism with severe oligozoospermia/asthenospermia (19.23%). There were no significant differences in the female age, female body mass index (BMI), female basic sex hormone level, PR% and the proportion of normal spermatozoa, number of oocytes retrieved and transplantation between study group and control group. When undergoing IVF-ET treatment, the implantation rate (17.42%), the clinical pregnancy rate (28.17%) in study group were significantly lower than those in control group (32.26%, 59.38%)(P<0.05). There was no significant increase in early abortion rate between the two groups. There was no significant difference in clinical outcomes between the two groups when undergoing ICSI-ET treatment. In addition, the good-quality embryo rate was higher in study group (75.24%±23.68%) than in control group (49.97%±29.31%) (P<0.05). In study group, the implantation rate (34.78%) and the clinical pregnancy rate (52.00%) were significantly higher among the patients undergoing ICSI-ET treatment than those undergoing IVF-ET treatment (17.42%, 28.17%) (P<0.05). Conclusion It suggests that male chromosome polymorphism can increase the ratio of severe oligozoospermia/asthenospermia. Male chromosome polymorphism has an adverse effect on IVF reproductive outcome and has no obvious effect on ICSI reproductive outcome. Key words: Male chromosomal polymorphism; Spermatozoa quality; In vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI); Pregnancy outcome; Yqh+; 1qh+