Anti-1-amino-3-[18F] fluorocyclobutane-1-carboxylic acid (anti-3-[18F] FACBC): Normal physiology and variant patterns of uptake

1359 Learning Objectives 1. Recognize normal physiological distribution patterns of anti-3-[18F]FACBC. 2. Recognize variants that may simulate disease. 3. Identify incidental uptake which may indicate malignancies other than prostate cancer. Anti-1-amino-3-[18F]fluorocyclobutane-1-carboxylic acid (FACBC) is a synthetic, non-metabolized, amino acid analog positron emission tomography radiotracer. Though uptake has been described in normal volunteers (J Nucl Med.2007;48(6):1017-20), the majority of patients have been studied in clinical trials involving prostate carcinoma. Normal physiologic background organ uptake patterns are similar to those noted in patients without cancer. Liver and pancreas demonstrate the most intense uptake. Typically on early images (