Prospective longitudinal assessment of the fetal left modified Myocardial Performance Index

AbstractIntroduction: The fetal left modified Myocardial Performance Index (Mod-myocardial performance index (MPI)) is a measure of systolic versus diastolic time intervals obtained from a single cardiac cycle with ultrasound. It is a measure of global ventricular function and has been investigated for potential utility in fetal conditions associated with cardiac dysfunction.Objectives: The objective of this study is to compare values from a precisely replicated fetal left Mod-MPI technique to published reference ranges.Methods: Three hundred and sixty-five nulliparae prospectively underwent fetal left Mod-MPI measurement at 27+0–29+0 and 35+0–37+0 weeks’ gestation. Measurements from pregnancies complicated by gestational diabetes mellitus, preeclampsia, or a small-for-gestational-age (<10th centile) infant were excluded. Mod-MPI values were compared with three published references created using similar measurement techniques.Results: Compared with one selected reference, at 29+0 and 35+0–37+0 weeks’ gest...