Acute Hemodynamic Effects of Porcine and Bovine Surfactant Replacement in Surfactant Depleted Newborn Piglets

Background: We have previously shown that instillation of 200mg/kg of porcine surfactant (Curosurf™) induces a systemic vasodilation in surfactant depleted newborn piglets. In the present work we wanted to study if this effect is dependent on dose and further could be induced also by instillation of a bovine surfactant preparation(Survanta™).