Sentinel Lymph Node Biopsy in Thyroid Cancer: It Can Work but There Are Pitfalls

Objective. The aim of this study is to retrospectively assess the specific perils associated with conducting sentinel lymph node biopsies to determine whether a central compartment neck dissection (CCND) is necessary in well-differentiated thyroid cancer. The goal was to assess the specific reasons for a false negative in 3 specific patients among a large population of thyroidectomy patients.Study Design. Case series with chart review.Setting. Three McGill University teaching hospitals that are part of the McGill University Thyroid Cancer Center in Montreal, Quebec, Canada.Subjects. Patients undergoing thyroidectomy and CCND for nodules suspicious for thyroid cancer (June 2009 to May 2010).Methods. Retrospective analysis of 157 patients who underwent thyroidectomy and analysis of CCND as a function of sentinel lymph node status on frozen section as determined by a pathologist at one of the participating centers.Results. Three patients were considered true failures or false negatives of the original protoc...