POLİKİSTİK OVER HASTALARINDA İNSULİN DİRENCİ, METABOLİK DURUM VE METABOLİK PARAMETRELER ARASINDAKİ İLİŞKİ

Aim: to investigate the hormonal status, insulin resistance, clinical and metabolic parameters and their correlation in polycystic ovary syndrome (PCOS) patients. Material And Methods: The study was performed on a total of 81 patients with menstrual irregularity, hirsutism and obesity who were admitted to Zekai Tahir Burak Women’s Health Educational and Research Hospital infertility and adolescent outpatient clinics between August 2010- August 2011. The serum levels of fasting insulin and glucose, 75 g oral glucose tolerance test (OGTT), low density lipoproteins (LDL), triglyseride (TG), high density lipoproteins (HDL), 17-hydroxyprogesterone, dehydroepiandrostenedione, androstenedione, total and free testosterone, thyroid stimulan hormon (TSH) were investigated, and body mass index (BMI), homeostasis model assessment of insulin resistance (HOMA-IR) scores were calculated for all participants. Results: On Body Mass Index (BMI) match tests; serum levels of fasting glucose, fasting insulin and 2. hour 75 gr OGTT results were significantly higher in patients with BMI>25 (n=32 %39,5) (p 25 (n=49 %60,5) serum levels of triglyseride were significantly higher than patients with BMI 25, no significant difference was determined in androgen profile parameters (p>0,005). Patients were splitted in two groups via Ferriman-Gallway (FG) scoring system. In patients with FG 8 (p<0,05). Conclusion : Insulin resistance; as defined in our study, was correlated with literature on BMI matched groups. Investigating the degree of insulin resistance may be helpful for physicians to predict the systemic morbidity of PCOS which develop on the basis of insulin resistance.