Silica Nanoparticle Coated Perfluorooctyl Bromide for Ultrasensitive MRI

MRI with hyperpolarized 129Xe can achieve low-concentration detection. Herein, nanoparticle-coated perfluorooctyl bromide (PFOB) was developed as 129Xe MRI contrast agent with moderate exchange rate, sufficient stability and feasible surface modification. The αvβ3 integrin overexpressed by non-small-cell lung cancer A549 cells was successfully detected by 129Xe MRI with high specificity through adequate surface modifications.