Synthesis and Biological Evaluation of (3′S)‐3′‐Deoxy‐3′‐fluoro‐3′‐C‐ethynylcytidine.
2012
The novel pyrimidine nucleoside, (3 ′S)-3 ′-deoxy-3 ′-fluoro-3 ′-C-ethynylcytidine (1) was synthesized from cytidine in seven steps. The key step in the synthesis was the introduction of the tertiary fluorine at the 3 ′-position. Compound 1 was evaluated in vitro against several RNA viruses.
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