MORFOLO(KI KARAKTERISTIKI NA STROMATA KAJ MALIGNITE EPITELNI NEOPLAZMI SO KRATOK OSVRT NA PLANOCELULAR НИОТ KARCINOM NA KO@ATA MORPHOLOGICAL CHARACTERISTICS OF THE STROMA IN MALIGNANT EPITHELIAL NEOPLASMS WITH SHORT REVIEW OF SKIN SQUAMOUS CELL CARCINOMA

The stroma of the neoplasm is a highly complex struc� ture built by : specialized mesenchymal cells typical for each tissue surroundings , cancer associated fibroblast/ myofibroblast, congenital or acquired immune cells , vas� cular network with endothelial cells and pericytes , mas� tocytes , macrophages , leukocytes and adipocytes , all to� gether incorporated in the extracellular matrix . Each neoplasm produces its own unique microenvironment where the tumor grows and modifies . Although most of the cells of the host in the stroma have compulsory tumor suppressor ability , the stroma is changing during the malignant process and it even promotes growth , in� vasion and metastasis . Genetic changes that occur du� ring the development of the cancer, which are guided by the malignant cells lead to changes in the stroma of the host that will overtake it and adjust it to their own needs . In the early stages of the tumor development and invasion , the basal membrane is degraded and the stroma becomes active and contains increased number of fibroblasts , inflammatory infiltrate and newly com� posed capillaries which come into direct contact with the tumor cells . These changes lead to cancer invasion .