Photooxidative vulnerability to intralipid in photodynamic therapy

This chapter is intended to help make inroads to the role of Intralipid in photodynamic therapy (PDT). In addition to Intralipid's favorable property as a light scattering agent, we hypothesized that it will be unstable to photosensitized oxidation. To explore this, measurements of total quenching rate constants (kT) of singlet oxygen with Intralipid and its constituents are described. Furthermore, organic phosphines were tested to trap Intralipid peroxides formed in photosensitized oxidation reactions. Our findings indicate that the vulnerability of Intralipid to photooxidation might suggest limits of its use in PDT.