Human and Rat Class IV Alcohol Dehydrogenases

Mammalian alcohol dehydrogenase (ADH, EC 1.1.1.1) is a complex enzymatic system composed of multiple molecular forms, which have been grouped into classes according to their enzymatic and structural characteristics. In addition to the three classes (I-III) early recognized (Vallee and Bazzone, 1983), more recent studies have led to the identification of three more classes: class IV (Pares et al., 1990, Pares et al., 1992), class V (Yasunami et al., 1991), and class VI (Zheng et al., 1993).