ВОЗРАСТНЫЕ ИЗМЕНЕНИЯ ПИК-ВОЛНОВЫХ РАЗРЯДОВ У КРЫС ЛИНИИ WAG/Rij С ГЕНЕТИЧЕСКОЙ АБСАНСНОЙ ЭПИЛЕПСИЕЙ, "Российский физиологический журнал им. И.М. Сеченова"

WAG/Rij rats are an experimental model of human genetic absence epilepsy, which is characterized by spike-wave discharges (SWDs) in the EEG. It is known that the first SWDs in WAG/Rij rats appear at the age of 2—3 months, and later on their number and duration increase. However, evolution of SWDs during the processes of absence epilepsy progressive development in WAG/Rij rats remains to be investigated. The aim of the present study was to find out the age-related changes in the time-frequency dynamics, frequency spectra and morphological characteristics of SWDs in WAG/Rij rats. To achieve this, the evolution of SWDs was investigated in the same rats at the age of 2 to 12 months. It has been established that SWDs are formed at the age of 2—4 months, and later on morphological changes of SWDs take place. It has been shown that during absence epilepsy progressive development SWDs successively passes three stages of «maturation». It is supposed that age-related evolution of SWDs in WAG/Rij rats reflects progressive electrophysiological changes in the somatosensory cortex, a brain region that is related with a generation and generalization of SWDs.