Cytostatic effect of homo-aza-steroidal esters in Vivo and in Vitro. Structure-activity relationships

The p-[N, N-bis (2-chloroethyl)amino)phenylacetate esters of 3β-hydroxy-N-methyl-17α-aza-D-homo-5α-androstan-17-one and 3β-hydroxy-17α-aza-D-homo- 5α-androstane have been prepared and their antitumor activity evaluated against L1210 leukemia, P388 leukemia, Ehrlich ascites tumor (EAT) and Lewis Lung Carcinoma (LLC)