Enzyme-catalyzed synthesis of optically Pure β-sulfonamidopropionic acids. Useful starting materials for P-3 site modified renin inhibitors.

Abstract The novel and efficient of several racemic β-sulfonamidopropionate esters is described. Treatment of the racemic esters with Chymotrypsin or Subtilisin Carlsberg (purified of detergent grade) provided the corresponding (S)-car☐ylic acids in 60–90% yield. These acids (75 to > 98% e.e.) are useful starting materials for the synthesis of P-3 site modified renin inhibitors.