Strategies toward improving the brain penetration of macrocyclic tertiary carbinamine BACE-1 inhibitors.
2007
This letter describes replacements for the P3 amide moiety present in previously reported tertiary carbinamine macrolactones. Although P-gp efflux issues associated with these amide-macrolactones were solved and full brain penetration was measured in one case, potency was compromised in the process.
Keywords:
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
17
References
36
Citations
NaN
KQI