AN ANTISENSE INHIBITOR OF APOLIPOPROTEIN C-III SIGNIFICANTLY DECREASES APOLIPOPROTEIN C-III, TRIGLYCERIDES, VERY-LOW-DENSITY LIPOPROTEIN CHOLESTEROL AND PARTICLE NUMBER, AND INCREASES HIGH-DENSITY LIPOPROTEIN CHOLESTEROL AND PARTICLE NUMBER IN HYPERTRIGLYCERIDEMIC PATIENTS ON A FIBRATE

Vickie Alexander,Daniel Gaudet,Wei Cheng,JoAnn Flaim,Steve Hughes,Walter Singleton,Richard S. Geary

AN ANTISENSE INHIBITOR OF APOLIPOPROTEIN C-III SIGNIFICANTLY DECREASES APOLIPOPROTEIN C-III, TRIGLYCERIDES, VERY-LOW-DENSITY LIPOPROTEIN CHOLESTEROL AND PARTICLE NUMBER, AND INCREASES HIGH-DENSITY LIPOPROTEIN CHOLESTEROL AND PARTICLE NUMBER IN HYPERTRIGLYCERIDEMIC PATIENTS ON A FIBRATE

2014

Vickie Alexander
Daniel Gaudet
Wei Cheng
JoAnn Flaim
Steve Hughes
Walter Singleton
Richard S. Geary

ApoC-III plays a pivotal role in regulating plasma triglyceride (TG) levels by inhibiting the hydrolysis of TG-rich lipoproteins and the receptor-mediated uptake of lipoprotein remnants by the liver and is recognized as a CV risk factor. ISIS-ApoCIIIRx selectively inhibits apoC-III protein synthesis

Keywords:

Very low-density lipoprotein
Apolipoprotein C-III
Lipoprotein
Cholesterol
High-density lipoprotein
Low-density lipoprotein receptor-related protein 8
Cardiology
Internal medicine
Endocrinology
Medicine
Triglyceride
Apolipoprotein C2
Fibrate

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