New heteroaromatic amides derivatives of 3 beta-amino azabicyclooctane, their preparation process and their applications in therapeutics.

Compounds of general formula 1 Formula 1 wherein A, B, D and E represent one or two nitrogen atoms, the others being a carbon atoms, X represents an S, or an O, thus forming a fused heteroaromatic system in bicyclo as thieno [2, 3-b] pyridine, furo [2, 3-b] pyridine, thieno [3, 2-b] pyridine, furo [3, 2-b] pyridine, thieno [2, 3 -b] pyrazine, furo [2, 3-b] pyrazine, thieno [2, 3-c] pyridine, furo [2, 3-c] pyridine, thieno [3, 2-c] pyridine and furo [3, 2 -c] pyridine, R1 represents an alkoxy group C1-C6, linear or branched alkyl group thio C1-C6 linear or branched, R2 represents a linear alkyl group, branched, cyclic C2-C8 group, a 2 thienylmethyl or 3, or a benzyl group optionally substituted by one or several substituents as halogens, F, Cl, Br, I, C1-4 alkyl, C1-4 Alcox, CF3, CN, NO2, OH, and salts thereof pharmaceutically acceptable.