Towards Identification of a Binding Site on Insulin-Like Growth Factor-II for IGF-Binding Proteins

Insulin-like growth factor (IGF) -I and -II mediate mitogenesis, differentiation and insulin-like metabolic effects.1 Their amino acid sequence is divided into 4 domains designated B-C-A-D beginning from the amino terminus. The B-and A-domains of IGF-I and IGF-II share substantial homology with each other and with the B-and A-chains of insulin.