Antitubercular Drugs Induced Liver Injury: A Case Series & Review

Tuberculosis (TB) is caused by tubercle bacilli, which belong to the genus Mycobacterium, namely Mycobacterium tuberculosis, Mycobacterium bovis, Mycobacterium africanum etc. Mycobacterial infections are among the most difficult of all bacterial infection to cure. Isoniazid, Rifampicin, Pyrazinamide are essential component of directly observed treatment short-course (DOTS) strategy to control TB by WHO & all the three agents is observed to cause potential hepatotoxicity. Here Causality assessment was done by using Roussel Uclaf Causality Assessment Method (RUCAM) / Council for International Organisations of Medical Sciences (CIOMS) Scale & Naranjo Algorithm. Here we have discussed four different cases of antitubercular drugs induced hepatotoxicity & also focussed on the management of the above condition.