Cheiro-oral-pedal syndrome in the lesion of thalamocortical projections

Abstract Unilateral sensory disturbance in the hand and mouth (cheiro-oral syndrome) is well known, but one in the hand, mouth and foot region (cheiro-oral-pedal syndrome) has been reported only in 2 patients with brainstem lesion and in 2 patients with thalamic infarction. We report the first case of cheiro-oral-pedal syndrome due to involvement of thalamocortical projections, which favors somatotopy in thalamocortical projections.